Phosphorylated Tau: Toxic, Protective, or None of the Above
نویسندگان
چکیده
منابع مشابه
Are Tau Aggregates Toxic or Protective in Tauopathies?
Aggregation of highly phosphorylated tau into aggregated forms such as filaments and neurofibrillary tangles is one of the defining pathological hallmarks of Alzheimer's disease and other tauopathies. Hence therapeutic strategies have focused on inhibition of tau phosphorylation or disruption of aggregation. However, animal models imply that tau-mediated dysfunction and toxicity do not require ...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2008
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-2008-14404